Embelia ribes Burm. is a large scandent shrub with long, slender, flexible branches belongs to the family Myrsinaceae. The plant is used traditionally in treating renal disorders. Current study was designed to scientifically evaluate the traditional claims of nephroprotective effect of Embelia ribes fruits alone and in combination with vitamin E against gentamicin-induced nephrotoxicity in rats. Nephroprotective effects of ethanol extract of Embelia ribes fruits alone (200 and 400 mg/kg, p.o), and in combination with vitamin E (α-tocopherol) (200 mg/kg, p.o) was studied against gentamicin (40mg/kg/day, i.p)-induced nephrotoxicity in rats for 14 days. Serum urea, creatinine and blood urea nitrogen were the parameters evaluated. The serum urea, creatinine and blood urea nitrogen levels in the gentamicin alone treated group were significantly elevated (P<0.01) with respect to control group, whereas the body weight was significantly lowered with respect to control group. The serum urea, creatinine and blood urea nitrogen levels were reduced in the Embelia ribes fruits extract treated and vitamin E treated groups. The renal levels of reduced glutathione (GSH) were declined in gentamicin alone treated group. The level of GSH were elevated significantly (P<0.05) the Embelia ribes fruits) and Embelia ribes fruits (200 mg/kg) with vitamin E (200 mg/kg) treated groups. Ethanol extract of Embelia ribes fruits alone and in combination with vitamin E, partially ameliorated gentamicin-induced nephrotoxicity.
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